解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:AIMS:(i) To investigate and compare the numerical aberrations of chromosomes 7, 8, 11, 17 and Y in a series of 60 adenocarcinomas of the oesophagus, gastric cardia and gastric antrum; and (ii) to specify the sequence of chromosomal aberrations occurring during the neoplastic progression of Barrett's oesophagus. METHOD...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2000.00887.x
更新日期:2000-09-01 00:00:00
abstract:AIMS:Central neurocytoma is a rare central nervous system tumour typically found in the lateral ventricles and at the septum pellucidum. Histologically, it resembles oligodendrogliomas and yet ultrastructurally, it shows neuronal differentiation. Its molecular oncogenesis is not known. The aim of this study was to exam...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2000.00977.x
更新日期:2000-08-01 00:00:00
abstract:AIMS:We compared the immunohistochemical profiles of the rete ovarii and endometriosis in order to identify a panel which distinguishes between these structures. The immune profiles of the epoophoron, Fallopian tube and ovarian surface epithelium were also studied. MATERIALS AND METHODS:Twenty-four women with no evide...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2000.00938.x
更新日期:2000-07-01 00:00:00
abstract:AIMS:Three cases with features of so-called 'Warthin-like tumour' of the thyroid (WaLTT) are described, in order to evaluate its relationship with papillary carcinoma (PC). METHODS AND RESULTS:We performed an histological and immunohistochemical study with emphasis on RET/PTC expression. The most striking features are...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2000.00925.x
更新日期:2000-06-01 00:00:00
abstract::Muciphages (mucin-containing macrophages), first described in 1966 by Azzopardi & Evans, are a common feature of biopsies of large intestinal mucosa, even in the absence of other abnormalities such as active inflammation or evidence of chronic inflammatory bowel disease. Should they be mentioned in diagnostic reports?...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2000.0954b.x
更新日期:2000-06-01 00:00:00
abstract::A variety of cytomorphological features, architectural patterns and stromal changes may be observed in malignant melanomas. Hence, melanomas may mimic carcinomas, sarcomas, benign stromal tumours, lymphomas, plasmacytomas and germ cell tumours. Melanomas may be composed of large pleomorphic cells, small cells, spindle...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2559.2000.00894.x
更新日期:2000-05-01 00:00:00
abstract:AIMS:Recent analyses have suggested that Hodgkin's or Reed-Sternberg (HRS) cells in most cases of classic Hodgkin's disease are derived from germinal centre B-cells. However, there is controversy over which B-cell antigens are expressed in HRS cells. METHODS AND RESULTS:We studied 51 cases of classic Hodgkin's disease...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2000.00830.x
更新日期:2000-04-01 00:00:00
abstract:AIMS:We have previously shown that hypertrophic scar tissue from burn patients contains abnormally high amounts of the proteoglycans versican and biglycan and reduced amounts of decorin, in comparison with normal dermis or mature scar. The lack of decorin may account for the poor organization of collagen fibrils in the...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2000.00824.x
更新日期:2000-03-01 00:00:00
abstract:AIMS:Cyclin D1 overexpression was examined in early gastric carcinomas and precursor lesions with the following aims; (1) to assess the chronology of cyclin D1 overexpression in various stages of gastric carcinogenesis, (2) to correlate cyclin D1 overexpression with the Lauren type, the grade of differentiation and the...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2000.00798.x
更新日期:2000-02-01 00:00:00
abstract:AIMS:Diversion colitis (DC) is a localized, relatively benign, iatrogenic condition which occurs in almost 100% of diverted colonic segments in patients who undergo ileostomy/colostomy for various reasons. The aim of this study was to establish histological features of DC in children. METHODS AND RESULTS:Twenty-three ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.2000.00803.x
更新日期:2000-01-01 00:00:00
abstract:AIM:To clarify the prognosis of melanotic schwannoma. This is a rare tumour which is generally considered as a benign lesion, reported in many cases with a short follow-up only. METHODS AND RESULTS:Five cases of spinal melanotic schwannoma were retrospectively studied. The tumours were examined using standard histolog...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1999.00786.x
更新日期:1999-12-01 00:00:00
abstract:AIM:Achalasia is a disease of the oesophagus characterized by increased lower oesophageal sphincter (LOS) tone, absence of LOS relaxation with swallowing and aperistalsis of the body of the oesophagus. The aetiology and pathogenesis of idiopathic achalasia is still controversial. METHODS AND RESULTS:We examined 16 oes...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1999.035005445.x
更新日期:1999-11-01 00:00:00
abstract:AIMS:The blastic variant of mantle cell lymphoma (MCL-BV) may develop through histological transformation of mantle cell lymphoma (MCL). However, the clonal link between the tumour cells of MCL and transformed MCL-BV has not been established at the genetic level. To investigate this link longitudinal molecular genetic ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1999.00745.x
更新日期:1999-10-01 00:00:00
abstract::Lobular carcinoma in situ and atypical lobular hyperplasia were first described over 50 years ago. Despite this long incubation period, the biological nature of the lesions remains controversial. They are generally regarded as 'risk indicators' of invasive cancer rather than true precursor lesions. When first describe...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2559.1999.00815.x
更新日期:1999-09-01 00:00:00
abstract:AIMS:Collagenous spherulosis (CS) is a rare lesion which is an incidental finding in breast and salivary glands. It is characterized by fibrillar spherules exhibiting an intrinsic radiating or concentric pattern which are surrounded by myoepithelial cells. This entity can be misdiagnosed as adenoid cystic carcinoma and...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1999.00757.x
更新日期:1999-09-01 00:00:00
abstract:AIMS:Small cell (neuroendocrine) carcinoma of the urinary bladder is clinically more aggressive than urothelial (transitional cell) carcinoma. We have investigated the immunohistochemical markers most useful in diagnosing small cell carcinoma in bladder. METHODS AND RESULTS:We evaluated the expression of chromogranin ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1999.00715.x
更新日期:1999-08-01 00:00:00
abstract:AIMS:Five cases of a characteristic low-grade thymic epithelial tumour are described that we suggest calling metaplastic carcinoma of the thymus. METHODS AND RESULTS:The patients' ages ranged from 44 to 71 (mean 56.2) years. Four of the patients were male. Three of five tumours showed invasion into mediastinal fat or ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1999.00691.x
更新日期:1999-07-01 00:00:00
abstract:AIM:We describe the unusual association of fallopian tubal prolapse and herpetic infection, an occurrence not previously reported to our knowledge. METHODS AND RESULTS:A 37-year-old woman presented with a small polypoid mass of the vaginal vault, 3 months after abdominal hysterectomy and abdominoplasty. The vaginal ma...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1999.00644.x
更新日期:1999-06-01 00:00:00
abstract:AIM:Clear cell chondrosarcoma (CCC) is a rare malignant cartilaginous neoplasm of bone. CCC is characterized by clear cells (CCC cells), osteoclasts and osteoblasts. Many important questions concerning the varied histological features of CCC, and the interactions between CCC cells and coexisting osteoclasts and osteobl...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1999.00656.x
更新日期:1999-05-01 00:00:00
abstract:AIMS:We evaluated polymerase chain reaction (PCR) amplification of specific immunoglobulin heavy chain (IgH) gene rearrangements as a means of demonstrating monoclonality during follow-up of conservatively treated gastric MALT lymphoma, and compared the reproducibility of PCR on sequential frozen and paraffin-embedded ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1999.00628.x
更新日期:1999-04-01 00:00:00
abstract:AIMS:Primary pulmonary sarcoma is rare, and frequently creates diagnostic challenges. We describe two cases of primary pulmonary spindle cell sarcoma in which a molecular approach using archival paraffin-embedded tissue was proved to aid diagnosis. METHODS AND RESULTS:Both patients had huge masses replacing the upper ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1999.00630.x
更新日期:1999-03-01 00:00:00
abstract:AIMS:Helicobacter pylori has been claimed to be an important aetiological factor which raises the risk of mucosa-associated tissue lymphoid (MALT) lymphoma. However, some studies on gastric MALT lymphoma revealed a low rate of H. pylori infection suggesting that not all gastric lymphomas are related to H. pylori infect...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1999.00597.x
更新日期:1999-02-01 00:00:00
abstract:AIMS:We investigated the phenotypic and cytotoxic characteristics of different types of peripheral T-cell and NK-cell lymphomas and correlated the findings of cytotoxic phenotype with Epstein-Barr virus (EBV) association. METHODS AND RESULTS:Eighty cases of peripheral T-cell and NK-cell lymphomas, classified according...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1999.00582.x
更新日期:1999-01-01 00:00:00
abstract:AIMS:Rosette-forming malignant lymphoma is very rare. We report a blastic NK-cell lymphoma expressing terminal deoxynucleotidyl transferase (TdT) with formation of Homer-Wright type pseudorosettes. METHODS AND RESULTS:An 18-year-old boy presented with an enlarged inguinal lymph node. Histologically, the nodal architec...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1998.00571.x
更新日期:1998-12-01 00:00:00
abstract:AIMS:There have been several cell kinetic studies of thymoma, but the effectiveness of using Ki67 antibody as a tool to measure proliferative activity in this tumour was rarely evaluated. We carried out an immuno-histochemical study using this antibody to assess the clinicopathological correlation and the prognostic si...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1998.00504.x
更新日期:1998-11-01 00:00:00
abstract:AIMS:To examine the usefulness of Hep Par 1 together with selected antibodies in the separation of hepatocellular carcinoma (HCC) from cholangiocarcinoma (CC), combined tumours (HCC-CC) and metastatic carcinoma. METHODS AND RESULTS:Antibodies to Hep Par 1, CK19, CK20 and factor XIIIa were applied to 32 HCCs, 27 CCs, f...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1998.00522.x
更新日期:1998-10-01 00:00:00
abstract:AIMS:Malignant transformation of Warthin's tumour (WT) is a rare event. We present two cases of mucoepidermoid carcinoma (MEC) arising in WT in the parotid gland. METHODS AND RESULTS:Two cases of MEC arising in WT, which were found in 185 cases of WT of the parotid gland, were investigated by light and electron micros...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1998.00502.x
更新日期:1998-10-01 00:00:00
abstract:AIMS:To evaluate the independent prognostic value of apoptotic versus proliferative fractions in a series of 92 patients with non-Hodgkin's lymphomas (NHL). METHODS AND RESULTS:Apoptotic fractions were quantified by use of the TdT (terminal deoxynucleotidyl-transferase)-mediated in-situ end-labelling technique (TUNEL)...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1998.00489.x
更新日期:1998-09-01 00:00:00
abstract:AIMS:We report a case study to elucidate the pathogenesis of polyarteritis nodosa (PAN) type vasculitis, a rare complication of familial mediterranean fever (FMF). METHODS AND RESULTS:A woman with amyloidosis complicating FMF underwent a cadaveric renal transplantation and 5 years later suffered an acute myocardial in...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1998.00462.x
更新日期:1998-08-01 00:00:00
abstract:AIMS:To study immunohistochemically a group of 28 primary lung cancers which demonstrated histological features reminiscent of those characteristic of regression in malignant melanoma, to determine the phenotype of their immune cell infiltrates. METHODS AND RESULTS:Using a standard s-ABC immunoperoxidase method then q...
journal_title:Histopathology
pub_type: 杂志文章
doi:
更新日期:1998-07-01 00:00:00
abstract:AIMS:In nodular sclerosing Hodgkin's disease (NSHD), the prognostic relevance of the histopathological grading in two subtypes NSI (low-grade) and NSII (high-grade) remains controversial. Analysis of follicular dendritic cells (FDC) may provide new prognostic parameters. METHODS AND RESULTS:Tumours from 59 patients wi...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1998.t01-1-00418.x
更新日期:1998-06-01 00:00:00
abstract:AIMS:Primary clear cell carcinoma of the pancreas resembling metastatic renal carcinoma has only rarely been described. To date it has been poorly characterized as a distinct tumour entity. METHODS AND RESULTS:We report a case of clear cell carcinoma in a 53-year-old man involving the head of the pancreas and which ha...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1998.00411.x
更新日期:1998-05-01 00:00:00
abstract:AIMS:Conflicting data on c-erbB-2 overexpression in gastric carcinomas can be found in the literature with regard to overall prevalence, prognostic significance and the histological type according to Lauren. The majority of these studies have focused on advanced gastric carcinomas whereas data on c-erbB-2 overexpressio...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1998.00376.x
更新日期:1998-04-01 00:00:00
abstract:AIMS:Intraosseous jaw cysts with a solely orthokeratinized lining epithelium have been suggested to differ from the typical odontogenic keratocysts (OKC) by exhibiting a less aggressive behaviour. We report 15 cases of such cyst type under the term of 'orthokeratinized odontogenic cyst (OOC)' and compared their clinica...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1998.00380.x
更新日期:1998-03-01 00:00:00
abstract:AIMS:The staining pattern of the recently described antibody melan-A was compared with those of S100 protein and HMB-45 in a variety of melanocytic lesions to assess the specificity and sensitivity of these antibodies. METHODS AND RESULTS:Immunohistochemical staining of paraffin sections of a range of melanocytic lesi...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1998.00312.x
更新日期:1998-02-01 00:00:00
abstract:AIMS:To establish the prevalence of CD44 protein expression in a large surgical series of Barrett's adenocarcinoma and associated preneoplastic lesions and to correlate this expression with clinicopathological data and prognosis. METHODS AND RESULTS:CD44H and variants (V4/V5, V6) expression was detected by immunohisto...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1998.00316.x
更新日期:1998-01-01 00:00:00
abstract:AIMS:To study the expression of the epithelial adhesion molecule E-cadherin and its associated proteins alpha and beta catenin in paraffin sections of normal ovaries, benign cystadenomas and ovarian carcinomas, and in immortalized normal ovarian surface epithelial cells and ovarian carcinoma cells in culture. METHODS ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1998.00341.x
更新日期:1998-01-01 00:00:00
abstract:AIMS:To evaluate the immunohistochemistry using an anti-mitochondria antibody in the investigation of various oncocytic lesions of the salivary glands. METHODS AND RESULTS:Ten cases of adenolymphoma (Warthin's tumour) and one case each of benign oncocytoma and oncocytic carcinoma of the salivary glands were examined. ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1997.2870891.x
更新日期:1997-11-01 00:00:00
abstract:AIMS:To describe a case of rhabdomyomatosis of the lung unassociated with other external or visceral malformations in a newborn infant. METHODS AND RESULTS:A 26 weeks gestation newborn male with no relevant medical or family history presented a well-circumscribed solid area in the posterior mediastinum occupying the u...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1997.2830880.x
更新日期:1997-11-01 00:00:00
abstract:AIMS:Adenoviral inclusions are commonly seen in appendices from infants with intussusception. They are associated with focal epithelial budding and less frequently with epithelial shedding. These morphological changes could depend on the opposing effects of adenoviral gene products on CD95-mediated apoptosis. METHODS ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1046/j.1365-2559.1997.2840875.x
更新日期:1997-10-01 00:00:00